Investigating the Mechanisms of Psychosis

Our ongoing studies utilize human postmortem tissue, quantitative fluorescent microscopy, discovery and targeted proteomics, genetic mouse models, and primary neuronal culture. Read more about the disorders we study below.

Psychosis in Alzheimer Disease

Schizophrenia

Individuals with schizophrenia have reduced auditory cortex gray matter volume, auditory hallucinations, impaired auditory sensory processing, and altered auditory event related potentials. Prior to our investigations, debate was ongoing whether these sensory impairments arose solely from deficits in “higher order” brain regions (top down impairments), or whether they reflected pathology within the auditory system (bottom up impairments).

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Psychosis in Alzheimer Disease

Psychosis in Alzheimer Disease

Psychosis affects about half of all patients with Alzheimer disease, causing additional burden to patients and their families. When present in Alzheimer disease, psychosis also serves as a predictor of a more aggressive course of illness, with more rapid cognitive decline and poor outcomes. Unfortunately, currently available treatments provide only limited relief of psychotic symptoms in Alzheimer disease patients, and do not prevent the more rapid decline.

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Training  Opportunities

Training Opportunities

I maintain an active interest in fostering the careers of young scientists, working with trainees at all levels.

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